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Endocrine Abstracts

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ea0077oc3.1 | Metabolism, Obesity and Diabetes | SFEBES2021

The serotonin transporter SLC6A4 protects human brown adipose tissue from serotonin-mediated suppression of thermogenesis.

Choong Kwok T’ng , Suchacki Karla , Ramage Lynne , Kelman Alexandra , McNeill Ben , Rodney Stewart , Keegan Matthew , Gray Calum , Manning Jonathan , MacNaught Gillian , Fletcher Alison , Simpson Joanna , Carter Roderick , Morton Nicholas , Homer Natalie , van Beek Edwin , Wakelin Sonia , Stimson Roland

The recent discovery of brown adipose tissue (BAT) in adult humans, which generates heat to maintain body temperature in a cold environment, offers an exciting new strategy to treat obesity and metabolic disease, but our knowledge of human BAT activation is limited. To identify novel pathways regulating human BAT, we undertook RNA sequencing of human brown and white adipocytes. The gene SLC6A4 (encoding the serotonin transporter SERT) was one of the most highly differ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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